Endocrine Abstracts

Background: Pituitary apoplexy is a rare clinical syndrome due to abrupt hemorrhaging and/or infarction of the pituitary gland, generally within a pituitary adenoma. The outcome of acute apoplexy is variable and difficult to predict. This explains why the optimal management of acute pituitary apoplexy remains controversial. The aim of our study was to investigate the clinical, hormonal and radiological characteristics of pituitary apoplexy and to determine treatment outcomes.<...

A 38-year-old woman presented with symptoms suggesting Cushing’s syndrome. She has a history of surgery of mature ovarian teratoma (hysterectomy, ovarectomy) associated to radio and chemotherapy 15 years ago. The malignant teratoma relaps with hepatic and grelic metastases, and was unresectable. Main complaints were weight gain with centripetal fat distribution, muscle weakness, melanodermia and purpule striae on the skin of the abdomen, thighs, breasts and arms....

Introduction: Insulinoma is rare tumor with an incidence of 1 in 250,000 patient-years. It presents with repeated episodes of hypoglycemia due to endogenous hyperinsulinemia, which occurs mostly in the fasting state. Insulinomas are usually sporadic, solitary, benign and encapsulated small lesions and majority of them measure <2 cm in diameter. They pose a challenge for pre-operative localization.Materials and methods: A retrospective study of patien...

Introduction: Nutritional management and adequate food intake is one of the fundamental cornerstones in the treatment of Type 1Diabetes Mellitus (Type 1 DM) to achieve optimal diabetes control, and reduced risk of micro vascular complications. Despite this emphasis on the importance of dietary education and management, the actual dietary intake of Tunisian adolescents with diabetes is not well documented.Aim: The aims were to describe the food and nutrie...

Introduction: Thiamine responsive megaloblastic anemia (TRMA) syndrome, also known Rogers syndrome is a rare autosomal recessive inherited disorder characterized by a triad features of megaloblastic anemia, sensorineural deafness and diabetes mellitus. TRMA manifestation is caused by mutations in the gene SLC19A2 encoding a high-affinity thiamine transporter, which disturbs the active thiamine uptake into cells.Case Presentation...

Introduction: The twenty-four hour nature of healthcare demands many nurses and midwives work in shifts. However night work shift is associated with adverse health outcomes like higher risks of obesity; and an unhealthy diet may be a contributing factor. Methods: A descriptive, cross-sectional study, carried out for one month, about midwives in delivery room in five university hospitals in Tunis. For this population there is no worker on the day but rath...

Introduction: Fanconi anemia (FA) is an autosomal recessive disease associated with chromosomal instability, it is marked by phenotypic heterogeneity. Patients with FS often exhibit growth retardation due to complex factors such as hypophosphatemia, metabolic acidosis, disturbed vitamin D metabolism. On the other hand, endocrinopathies are a common feature of FA specially such as Growth hormone deficiency (GHD). We report here two cases of Fanconi disease associated to GH defi...

Introduction: GH deficiency (GHD) represents less than 20% of short stature in children, the clinical, biological and radiological characteristics differ from one population to another.Methods: Our retrospective study describe 59 children (37 boys and 22 girls) with confirmed GHD. The average age of discovery was 95 months. About 20.3% of these children were born from a consanguineous marriage. Family history of anterior pituitary insufficiency was prese...

Introduction: Cushing’s syndrome (CS) is rare in children. The most common cause of CS in children is exogenous or iatrogenic CS. The most common cause of endogenous CS is Cushing disease (CD). Pediatric CD is almost always caused by a pituitary microadenoma. Here we present a rare case of (CD) related to pituitary macroadenoma.Clinical observation: An 11 year old boy presented with complaints of excessive appetite and progressive weight gain. He ha...

Introduction: 11β-Hydroxylase deficiency (11β-OHD), caused by CYP11B1 mutations, is characterized by hyporeninemic, hypokalemic hypertension and hyperandrogenism. We studied the mutations of CYP11B1 gene in two patients with classic 11β-OHD.Observations: We present the first case of a 23 year old boy with preliminary diagnosis of 21 β-OHD diagnosed at the age of 10. The patient presented with hypertension and hypokalemia which were ag...